Stable gastric pentadecapeptide BPC 157 and wound healing

Review of findings on BPC 157 in wound models (incisions, burns, diabetic ulcers) in rats and mice; mechanisms via the NO system and angiogenesis are discussed.

Key points

• Findings from rodent models of skin wounds, burns and ulcers are summarised.
• Vascular responses, platelet function and collagen formation are discussed as possible mechanisms.
• The authors come predominantly from the research group that developed the peptide.

Assessment

Evidence type: preclinical. All findings come from animal models. The paper should be read as a review by a single research group; independent replication is largely lacking. Profile: BPC-157.